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Issue 3 - May, 2015                                                                                            Follow us on Twitter!  @UCSF_Catalyst

In This Issue:

  • UCSF-CTSI Catalyst News
  • Update on Past Catalyst Awardee
  • Translational Research Funding Opportunities
  • Upcoming Events
  • Launchpad-Keys to Success

 Catalyst News:

  • UC Medical Campuses Lay Framework for Drug Discovery Alliance 

    On April 15, 2015, more than forty leaders from across the University of California (UC) system joined representatives from the biomedical industry to discuss plans for strengthening UC’s position as a leader in drug, device and diagnostics development. The meeting was part of the Drug and Device Discovery and Development (D4) initiative, a collaborative effort among UC’s five medical campuses to pool resources and expertise to accelerate the discovery and development of products that improve health. Read the full story here and link to additional event coverage by BioCentury Innovation
 
  • Catalyst Seminar Series: Commercializing Diagnostics in the Era of Precision Medicine 

    On May 8, 2015, the Catalyst team brought together the industry leaders in diagnostics development for a panel discussion on the opportunities and the challenges in the field.  Addressing the audience of academic researchers and entrepreneurs, the panel encouraged the audience to think early about the later-stage clinical validation studies, regulatory and reimbursement paths, and IP strategy for their inventions.  Event recording is available here. Panelists flyer.
 
  • Genentech's Sean Bohen, to give keynote address at Catalyst Report Out
Can Big Data Take the Place of Animal Models? 
The Potential of “-omics” and Real World Data in Drug Development
Sean Bohen, MD, PhD, Senior VP, Genentech Research and Early Development (gRED) will give the keynote address prior to the Catalyst Awards Spring 2015 report-out. During his tenure at Genentech, Sean led clinical development of many highly successful therapeutics, including Rituxan, Ocrelizumab, Xolair, and Pulmozyme.  
June 3, 2015 (11-12pm), Byers Auditorium.                  Open to public, please RSVP and event Flyer.
Moving Towards the Clinic:  

ChemoFilter, a Catalyst Awardee, is acquired by Penumbra, Inc.
Anand Patel, MD and Steven Hetts, MD from the Department of Radiology came to the Catalyst Awards program in the Fall of 2012 with a project aimed to improve the delivery of chemotherapeutics to a tumor site in transarterial chemoembolization (TACE) procedures.  Their proposed solution to the problem of toxicity and dose limitation in TACE was an endovascular device for trapping unbound chemotherapeutics downstream of the targeted organ.

The Catalyst advisors helped the investigators to design prototypes, while the award gave them the opportunity to demonstrate proof-of-concept in animal models.  Catalyst’s support served a springboard for further funding and company formation, with Dr. Al Chin joining the founders team.   In April 2015, ChemoFilter completed a deal with Penumbra, Inc, a major medical device company, to finalize the design, take the
device through FDA approval and to commercialize the filter.  In addition, 
the investigators received a significant R01 grant from NIH to collaborate with UC Berkeley, University of Wisconsin and CalTech to broaden the applications of the ChemoFilter concept to different types of Chemotherapeutics and procedures.

Translational Research Funding Opportunities:

  • Michael J. Fox Foundation: Target Advancement & Therapeutic Pipeline programs in Parkinson’s translational research. Funding levels vary. Due May 27;
  • Pfizer Aspire Cardiovascular Grant: Basic and translational research on the role of PCSK9 in health and disease. Up to $100K. LOI due May 28;
  • Alex's Lemonade Stand Reach Grant Program: support late translational studies towards a clinical trial in pediatric cancers. Up to $125K. Due May 29;
  • Rosenman Innovation Awards: supports medical device development. Up to $15K In in-kind services, $15K 1st prize, $10K 2nd prize. Due June 3rd;
  • Wellcome Trust Seeding Drug Discovery: funding for early stage (screen-to-lead) & late stage (lead-to-clinical) drug discovery projects. Funding levels are project-specific. Pre-apps due June 5;
  • Alzheimer’s Drug Discovery Foundation: preclinical drug discovery & biomarker development. Up to $150K. Due June 16;
  • Epilepsy Foundation: New Therapy Commercialization Grant Program. Up to $100K. LOI due Aug 14;
  • Bayer Grants 4 Targets: Novel Drug Targets & Biomarkers in Oncology, Gynecology, Cardiology, Hematology, Ophthalmology. Up to €125K. Due Aug 31;
  • NIH SBIR/STTR Program: Due Sep 5, Jan 5, April 5;
  • The Biomarker Factory: funds biomarker projects from early discovery to validation studies. Up to $800K. Rolling deadline;

Upcoming Events:

 
UCSF
  • Starting Up Science: An Intimate Gathering of Thought Leaders in the Life Science/Healthcare Startup Community. May 21 (1-7pm) QB3, 953 Indiana St., Register
  • Digital Health Summer Summit: June 18-19Register
  • 2nd Annual Rosenman Institute Symposium: How Precision Medicine is Transforming Medical Devices: Join Bay Area stakeholders to share insights and discuss how entrepreneurs can bring new technologies to market for the benefit of patients. June 24 (1-5:30pm),  Register now   
Community
  • California Life Sciences Association Open House & Kick Off: South San Francisco, CA; June 3 (5-7:30pm) Register;
  • Spring 2015 FAST Showcase and Celebration:  Participants of the BayBio Institute for the exclusive Fellows All-Star Team (FAST) will showcase their technologies to an audience of investors, life science startups and executives from all segments of the industry. June 9 (5-8:30pm), UCSF Mission Bay, Read more… 
  • BIO International Convention: Philadelphia, PA, June 15th-18th,  Register;
  • The Clinical Genome Conference: New findings and solutions for advancing the applications of clinical genome medicine. San Francisco, June 22-24Register;
  • UC Berkeley Extension: Principles of Regulatory Affairs, Berkeley, CA July 1-2Registration;
  • New Possibilities & Challenges with the Precision Medicine Initiative: An Evening with Thought Leader Dr. Craig Venter, Co-Founder & CEO of Human Longevity, Inc; Newport Beach, July 9 (4-6pm) Register;

UCSF-CTSI Catalyst Awards Program
University of California, San Francisco (UCSF)
CTSI, Box 0558
550 16th Street (at corner of 4th St.)
6th Floor, San Francisco, CA 94158


Catalyst Awards Program | Early Translational Research | UCSF Profiles

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June
3
Sean Bohen  Keynote Address
(11-12pm) 

Mission Bay, Byers Auditorium
Open to public. Please RSVP, event Flyer.
June
9
Spring 2015 FAST Showcase
(5-8:30pm)
Mission Bay, Byers Auditorium  
           By Invitation
 
June
15-18
Bio International Convention –
Register
Philadelphia, PA
June
24
Symposium: How Precision Medicine is Transforming Medical Devices 
(
1-5pm) Mission Bay, Byers Auditorium  Register

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