DNDi E-news
November 2014   |   View Online

Strengthening the malaria treatment arsenal for children in Africa


Viewpoint by Dr Bernhards Ogutu and Dr Sodiomon Sirima

Malaria is the leading parasitic cause of morbidity and mortality worldwide with African children under five years of age being the most severely affected. In 2012 alone, the disease killed an estimated 482,000 children: that is 1,300 children every single day. More »

Anti-Malarial ASMQ FDC: Safe and effective for young children in Africa

Results of a five-year-long clinical trial in three African countries in children under 5 years old with uncomplicated falciparum malaria show safety and efficacy of ASMQ FDC is not inferior to Artemether-Lumefantrine (AL) FDC. More »

Kala-azar treatments in Bangladesh: Study results support WHO recommendations

Clinical trial comparing efficacy and safety of short-course drug combinations (with AmBisome®, miltefosine, paromomycin) with AmBisome® alone against kala-azar in Bangladesh shows excellent cure rates and tolerability. More »

Prize for innovative cooperation model for malaria is awarded to DNDi in Brazil

The Funding Authority for Studies and Projects (FINEP) of Brazil’s Federal Government awards DNDi Latin America for its innovative cooperation model for developing ASMQ in Brazil with pharmaceutical company Farmanguinhos. More »

Bill & Melinda Gates Foundation announces USD 60 million grant to DNDi to fill R&D gaps

DNDi has been awarded USD 60 million by the BMGF towards its clinical development of new treatments for sleeping sickness, river blindness, and kala-azar. More »

DNDi signs strategic collaboration in Colombia

Ruta-N and DNDi establish a strategic alliance, with an initial contribution of USD 647,500. The joint programme begins with an evaluation of alternative topical therapies for cutaneous leishmaniasis. More »


Journal of Antimicrobial Chemotherapy:
Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis More »

Antimicrobial Agents and Chemotherapy:
Biomarkers to monitor therapeutic response in leishmaniasis: a systematic review More »

Journal of Biomolecular Screening:
Drug discovery for human African trypanosomiasis: Identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei More »

Antiviral Therapy:
Lopinavir/ritonavir plus lamivudine and abacavir or zidovudine dose ratios for paediatric fixed-dose combinations More »

Health Affairs:
Improving access to malaria medicine through private-sector subsidies in seven African countries More »

European Journal of Pharmaceutical Sciences:
In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis More »
DNDi gana el premio FINEP en Brasil »
DNDi firma colaboración estratégica en Colombia »

DNDi ganha prêmio FINEP no Brasil »
DNDi assina colaboração estratégica na Colômbia »


Legal Officer (short term) »
Coordinateur de la Plateforme THA »

PharmaTimes: "FDA priority review voucher scheme under fire"

El Mundo: "Firman alianza para estudio de enfermedades olvidadas"

Daily Nation: "New drug offers hope in fight against malaria"

Priorité Santé, RFI: "Résultats d’une étude antipaludique pour les enfants en Afrique"

Forbes: "Bill Gates Gives $500 Million To Fight Malaria, Other Diseases"

SciDev.net: "Médicos de América plantean acciones contra chagas a 2020"

El Mundo: "Cada vez más cerca la pomada contra la leishmaniasis"
SciDev.net: "UK universities to be scrutinised on global health research"
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