Cell culture systems that allow you to grow cells under more physiologically relevant conditions is emerging as the new golden standard for cell-based research, therapy and drug discovery. Recent publications from researchers at Novo Nordisk and Icagen Inc., highlight the importance of biorelevant culture substrates for improved cell assays.
BioLamina offers an expansive portfolio of defined and xeno-free hr Laminin cell culture matrices for a variety of cellular applications, including reliable expansion of hPSCs and differentiation and maintenance of specialized cell types.
"Laminin-521 shifts away from the paradigm that muscle cells lose their ability to differentiate after culturing.
Muscle differentiation on laminin-521 is nothing short of spectacular, yielding increased numbers of nuclei per myotube and improved myotube organization. Surprisingly, muscle cells expanded on laminin-521 maintain their ability to differentiate into myotubes after long-term passaging, better resembling differentiation of freshly isolated cells.
Muscle cells grow 2-3 times more rapidly on laminin-521 compared to other substrates. On laminin-521, 90-100% of muscle cells are simultaneously in the cell cycle compared to about 50% or less on other commonly utilized substrates. I believe by attaining uniform expansion it may be possible to reduce selection processes that often plague traditional muscle cell culture.
For drug discovery purposes, laminin-521 allows you to rapidly expand muscle cells into 100 million cells or greater while maintaining excellent differentiation; it’s a win-win."
Dr. Christopher Penton, Research Investigator, Icagen Inc., USA
Visit our science room for more information about our human recombinant laminin cell culture substrates. Please do not hesitate to contact me for more information about our products and how we can help you with your hPSC research.