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Latest Issue | Archives | News | Forums | Protocols 07/19/2012

Science Publishing

Open Access, But Same Impact

By Jesse Jenkins
By comparing two-year impact factors for journals, researchers found that open access and subscription-based journals have about the same scientific impact.

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Posters & Protocols

The BioTechniques Poster Hall and Protocol Guide features sponsored posters and protocols that provide information about specific methods.

Nucleic Acid Purification

Automated Extraction of High Quality DNA from 1—16 Blood Samples

Extracting pure DNA from whole blood is challenging. Mammalian blood has few DNA-containing cells and the large amounts of haemoglobin and plasma proteins can clog up extraction matrices and inhibit downstream applications. There is always a risk that blood samples contain harmful infectious agents. GeneMole® is a new bench-top automated system for extraction of high quality nucleic acids from many different sources, including blood. The system processes up to 16 samples/run; 8 samples in 28 min. GeneMole® handles sample volumes ≤200 µl. Reagents are pre-filled in individually sealed strips (MoleStrips™) for maximum convenience and safety.

 

High Throughput

Predictive Assays for High Throughput Assessment of Cardiac Toxicity and Drug Safety

A large percentage of new drugs fail in clinical studies due to cardiac toxicity. Therefore development of highly predicative in vitro assays suitable for high throughput screening (HTS) is extremely important for drug development. Human cardiomyocytes derived from stem cell sources can greatly accelerate the development of new chemical entities and improve drug safety by offering more clinically relevant cell-based models than those presently available. Stem cell derived cardiomyocytes are especially attractive because they express ion channels and demonstrate spontaneous mechanical and electrical activity similar to native cardiac cells. Here we demonstrate cell based assays for measuring the impact of pharmacological compounds on the rate of beating cardiomyocytes with different assay platforms.

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New Podcast:
Next Generation Model Organisms: Benchtalk, Episode 4

New product:
UV-Gain Flattening Filters

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