Benchmarks - Biomedical Research Highlights of PENN Medicine
Issue 1, December 2008
Editors' Note

Welcome to Benchmarks, a new e-newsletter bringing you news highlights about basic science research at PENN Medicine. This inaugural issue features basic research in neuroscience, infectious diseases, and cardiovascular disease; look for future editions to include other areas of basic research as well. We hope that you will enjoy these periodic updates, and we value your feedback as we strive to improve these communications. Enjoy!

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Neuroscience @ PENN Medicine
Searching for Shut-Eye

Fruit Fly

Photo by chromalux

Investigators have long been puzzled about what governs the need for slumber. In a recent study of fruit flies, they have identified a gene that controls sleep.

>>Article in Science Magazine *
>>Article in the Philadelphia Inquirer

Stories feature the research of Allan Pack, MD, PhD of the Penn Sleep Center, David Raizen, MD, PhD from Penn's Department of Neurology, and Amita Sehgal, PhD, from the Department of Neuroscience.

New Models of Neurodegeneration

TDP43

Image courtesy of Virginia Lee

This Nature News feature reappraises the way drugs are tested in animal models of neurodegeneration.

>>Article in Nature News *

Virginia Lee, PhD, Director of Penn's Center for Neurodegenerative Disease Research, is featured.

Infectious Disease @ PENN Medicine
New DNA Weapon Against Bird Flu

By delivering a vaccine via DNA constructed to build antigens against bird flu, researchers have immunized experimental animals against various strains of the virus.

>>Video from FOX29 News
>>Article in the Daily Pennsylvanian

Stories feature Dominick Laddy, PhD and David B. Weiner, PhD of Penn's Department of Pathology and Laboratory Medicine.

Bird Flu poster

Photo by augapfel

Zinc Finger Proteins Put Personalized HIV Therapy Within Reach

Using minute naturally occurring proteins called zinc fingers, researchers are engineering T cells to one day treat AIDS in humans.

>>Audio and transcript from WHYY Radio
>>Video and article on ScienCentral
>>Article in the Daily Pennsylvanian
>>Blog on Wired Science
>>Article in the Telegraph (UK)

Stories feature Carl June, MD of the Penn Department of Pathology and Laboratory Medicine and Elena Perez, MD, PhD of the Department of Pathology and Laboratory Medicine and the Children's Hospital of Philadelphia.

Zinc Finger

Image courtesy of Sangamo


Cardiovascular Disease @ PENN Medicine
New Class of Heart Disease Medication

Arteries

Image courtesy of Robert Wilensky

The drug darapladib can inhibit a cholesterol-and-immune-associated protein, reducing the development of heart-disease plaques in an animal model.

>>Article from UPI News Service

The story features Robert Wilensky, MD, of the Penn Cardiovascular Institute.

Breakthroughs with Bee Venom

Honeybee

Photo by _skender_

A honeybee venom toxin is used to study ion channels and their relation to hypertension.

>>Article in the Times Online (UK)

The research of Zhe Lu, MD, PhD, Professor of Physiology at Penn, is featured.
Benchmarks is a periodic e-newsletter highlighting basic science research at PENN Medicine that has been featured in the news. We value your feedback as we strive to improve these communications.

About the header graphic: Image depicts vascularization in a mouse embryo yolk sac. By Andrea Stout.
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Published and distributed by the PENN Medicine Department of Communications:
Editorial Staff
Karen Kreeger, Senior Science Communications Manager
Rachel Ewing, New Media Specialist

Administration
Susan E. Phillips, Senior Vice President for Public Affairs
Marc S. Kaplan, Director of Communications

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