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 Microbiology @ Penn Medicine“Good” Bacteria Keep Immune System PrimedAltering the intricate dynamic between resident and foreign bacteria – via antibiotics, for example – compromises an animal’s immune response.
The research of Jeffrey Weiser, MD, professor of Microbiology and Pediatrics, and Thomas Clarke, PhD, a postdoctoral fellow in the Weiser lab, is featured.  Science Illustration @ Penn MedicineVisualizing Nature
 A 15-foot-wide, walk-through model of forces acting on developing lung cells is a winner in this year's International Science & Engineering Visualization Challenge.
Co-Directors of LabStudio, Peter Lloyd Jones, PhD, associate professor of Pathology and Laboratory Medicine, and Jenny E. Sabin, MArch, lecturer in Architecture, School of Design, led the winning team. Source: American Association for the Advancement of Science, National Science Foundation Physiology @ Penn MedicineAntioxidant in Vegetables Has Implications for Treating Cystic FibrosisThiocyanate reduces damage by inflammatory molecules in lung, nerve, pancreas, and vessel-lining cells. The research of Zhe Lu, MD, PhD, professor of Physiology; and Yanping Xu, MD, PhD, senior research investigator, and Szilvia Szép, PhD, postdoctoral researcher, both of the Department of Physiology, was featured.  Genetics @ Penn MedicineAutism in Top Ten Research identifying multiple genetic variants linked to autism spectrum disorders was named one of TIME magazine’s Top 10 Medical Breakthroughs The research of Gerard Schellenberg, PhD, professor of Pathology and Laboratory Medicine, and Maja Bucan, PhD, professor of Genetics, is highlighted Orthopaedics @ Penn MedicineFirst Clear Idea of How Rare Bone Disease ProgressesA mutation causing “leaky” protein production leads to extra bone growth in rare genetic disorder called fibrodysplasia ossificans progressive.
The research of Eileen Shore, PhD, professor of Genetics and Orthopaedics; Mary Mullins, PhD, professor of Cell and Developmental Biology, and Frederick Kaplan, MD, the Nassau Professor of Orthopaedic Molecular Medicine, was featured.  Ophthalmology @ Penn MedicineSecond Dose of Gene Therapy Safe in Animal Studies A second injection of genes into the opposite, previously untreated eye is safe and effective, giving patients with rare blinding disease continued hope. The research of Jean Bennett, MD, PhD, F.M. Kirby professor of Ophthalmology is featured. Neurobiology @ Penn MedicineBundle of NervesLab-grown nerve bundles physically bridge previously irreparable injuries in animal models. The research of Douglas Smith, MD, professor of Neurosurgery and director of the Center for Brain Injury and Repair, is featured.  Three Brain Diseases Linked by Same Toxic ProteinParkinson’s disease, Alzheimer’s disease, and Huntington’s disease are linked by a toxic form of Elk-1. The research of James Eberwine, PhD, co-director of the Penn Genome Frontiers Institute and the Elmer Holmes Bobst Professor of Pharmacology; Anup Sharma, an MD-PhD student in the Eberwine lab, and Jai-Yoon Sul, PhD, assistant professor of Pharmacology, is featured.  Genetics of Common Form of Early-Onset DementiaUsing a genome-wide scan for genetic variation, researchers pinpointed variations common to patients with a specific subtype of frontotemporal lobar degeneration. The research of Vivianna Van Deerlin, MD, PhD, associate professor of Pathology and Laboratory Medicine; Virginia Lee, PhD, director of the Center for Neurodegenerative Disease Research; John Q. Trojanowski, MD, PhD, director of the Institute of Aging; Maria Martinez-Lage, MD, postdoctoral fellow in Pathology and Laboratory Medicine; and Alice Chen-Plotkin, MD, Instructor in the Department of Neurology, is featured.  |
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